UGM Lecturer Researches the Incident of Neo-Intimal Hyperlasia

TIMESINDONESIA, YOGYAKARTA – Indonesia ranks the 61st in the world from a country where the population died of coronary heart disease. The Gajah Mada University (UGM) lecturer is now researching the incidence of Neo-Intimal Hyperlasia.

Coronary heart disease is a disease characterized by plaque or atherosclerosis in the coronary arteries.

Thus, the blood vessels become narrowed and cause sudden symptoms of chest pain. Well, one attempt to treat it is a coronary bypass surgery, balloon angioplasty or the installation of a stent (heart ring). Lately, the use of stents for the treatment of coronary heart disease in Indonesia has increased.

"Therefore, it is necessary to start the detection of coronary heart disease by using biomarkers that have an important role in the initiation and resolution of inflammation after the presence of vascular jejas," said FKKMK UGM heart disease lecturer, Dr. Hariadi Hariawan.

According to him, the installation of bare metal stents (BM) is clinically beneficial. Only, it is still followed by the occurrence of neo-intimal hyperplasia of the blood vessels that are installed stents due to the migration and proliferation of vascular smooth muscle cells.

"To find out the effect of stent of BM placement, it is necessary to do a study of Neo-Intimal Hyperlasia incidence in animals with bare metal stents," Hariadi said.

Hariadi himself has experimented on ten rabbits. The six rabbits were given BM stents and four rabbits as controls without stents. Next procedure is blood testing for miRNA and cytokine iflamation.

"From blood samples then they were examined, miRNA-2, miRNA-24, IL-6 and IL-8 and abdominal aortic blood vessel tissue, then examined anatomical pathology to see the presence of neointima hyperplasia," Hariadi explained.

From this study, it was found that rabbits with BM stents were attached to an increase in the ratio of miRNA-21 / miRNA-24 on the 7th day.

"There has been an increase in Neo-Intimal Hyperlasia from the mild category to the moderate category," said Hariadi

Hariadi explained, on the 28th day there was a decrease in the ratio of miRNA but there was an increase in Neo-Intimal Hyperlasia from moderate category to the heavy category. "Perhaps this is due to the role of other miRNAs that affect the Neo-Intimal Hyperlasia incident," he explained.

Even though it was only preliminary research, Hariadi said that the further research needed using experimental animals that were closer to similarities to human anatomy such as pigs. "In addition, research should also use stents coated with drugs," he said. (*)

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